WebApr 14, 2024 · The presence of Hg 2+ seriously inhibited the expression of functional genes relevant to the iron and sulfur metabolism of A. ferrooxidans ATCC 23270, and the expression of mercury-resistant genes was higher in earlier stages of growth than in the later stages of growth for the groups with aerobic iron and sulfur oxidation and the anaerobic … WebMar 15, 2024 · These studies suggest that regulation of iron metabolism related gene expression is consequential for a cancer cell to survive the harsh conditions. Role of iron in the pathophysiology of cancer. Research has demonstrated the abnormality of iron homeostasis in several cancers including breast, ...
An overview of molecular basis of iron metabolism regulation and …
WebXVII Summary and Conclusions. Iron metabolism is regulated in cells to ensure that iron supplies are adequate and nontoxic. The expression of iron metabolism is regulated … WebOct 22, 2024 · The molecular function of iron metabolism-related genes (IMRGs) is mainly enriched in active transmembrane transporter activity, and they mainly affect the biological process of response to oxidative stress. Ferroptosis and fluid shear stress and atherosclerosis pathways may be the critical pathways regulating iron metabolism in IPAH. triangle pose benefits
Iron and leukemia: new insights for future treatments
WebOct 10, 2024 · Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status. Small heterodimer partner-interacting leucine zipper protein (SMILE), a polyphenol-inducible transcriptional co-repressor, regulates hepatic … WebJan 4, 2024 · The iron metabolism-related genes were mostly implicated in retinol metabolism pathways, chemical carcinogenesis, and arachidonic and metabolism pathways, according to pathway enrichment analysis ( Figure 2E ). FIGURE 2 FIGURE 2. Functional enrichment analysis of dysregulated iron metabolism-related genes in TCGA-PAAD cohort. WebMay 22, 2024 · Sixteen iron metabolism-related gene sets (GO_IRON_ION_BINDING, GO_IRON_ION_IMPORT, GO_IRON_ION_TRANSPORT, GO_RESPONSE_TO_IRON_ION, HEME_BIOSYNTHETIC_PROCESS,HEME_METABOLIC_PROCESS, REACTOME_IRON_UPTAKE_AND_TRANSPORT, … tension chin up bar