Web1 de ago. de 2024 · Currently, four reference models are available: (i) HSA model, where the synergy score quantifies the excess over the highest single drug response; (ii) … Web13 de nov. de 2024 · For example, IBR+VEN showed enhanced efficacy in RCH-ACV B-ALL cells and showed synergy for the majority of drug-pair concentrations by the highest single agent (HSA) method (ibrutinib, venetoclax, and …
Highest Single Agent (HSA) - Horizon Discovery
Web23 de dez. de 2024 · Of note, among the top 10 hub genes, STAT3 was the transcript with the highest number of predicted 3′UTR target sites, being a target of hsa-miR-125a-5p. STAT3 is transcriptionally hyperactive in numerous tumor cells and serves as an immune checkpoint in immune-associated tumor cells [ 89 , 90 ]. Web9 de dez. de 2024 · We initially developed the DECREASE method based on an in-house compendium of 192 anticancer agent combinations among both approved drugs and investigational compounds, tested in 8 × 8 dose ... flooring transition in doorway
hsa function - RDocumentation
Web1 de set. de 2015 · We note that, max ( y1, y2) is also the expected response from a popular reference model, called highest single agent (HSA) model ( Berenbaum, 1989 ). If the combination response yc is lower than max ( y1, y2 ), then one would intuitively infer antagonism. Therefore, we may use max ( y1, y2 ), to distinguish antagonism from non … WebFunctions in synergyfinder (0.1) CalculateSynergy. Calculate the synergy scores for drug combinations. ZIP. Delta synergy score based on zero interaction potency (ZIP) model. BaselineCorrectionSD. Baseline correction for the dose-response matrix of drug combinations. mathews_screening_data. Web17 de mai. de 2024 · Genedata Screener Synergy Module analytic software (Basel, Switzerland) was used to quantify the effect of combination using HSA (Highest Single Agent), Bliss independence, and Loewe... flooring transitions carpet to tile