Drugs containing convallatoxin

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August undefined, 2024

WebConvallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. WebWe identified convallatoxin, a novel cell-targeting antiviral that inhibits CMV infection by decreasing the synthesis of viral proteins. At doses low …

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WebMaterials and methods: Aliquots of a drug-free serum pool and a digoxin serum pool were supplemented with nanograms to 1 μg quantities of convallatoxin or 1.0 and 2.5 μL of lily of the valley extract per milliliter of serum followed by measurement of digoxin concentrations using the LOCI and ADVIA Centaur digoxin assays. WebFeb 15, 1986 · Very interestingly, when the mutant cells are grown in cardiac glycoside-containing medium, the resistant form of the enzyme accounts for about 50-60% of the total enzyme. These results show that both classes of SCR mutants are affected in Na+/K+-ATPase and that the amount of the resistant enzyme in the mutant cells is regulated in … is sound wave transverse or longitudinal

Convallatoxin - Wikipedia

WebConvallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective … WebHerbal medicines have been effectively used for the treatment of cardiovascular diseases for many years. ... (whole plant extracts) 80-900 mg per day; containing 1.5 mg Vitexin (Crataegus flavanoid) bid Lily of the Valley Root (Convallaria) 100-400 mg per day, containing Convallatoxin (Convallaria alkaloid) 0.4 mg bid WebOver the years, convallatoxin has been recognized as a potential novel drug to treat malignant tumors due to its strong anti-cancer activity and chemotherapy sensitization effect . Schneider et al. [ 5 ] have reported that convallatoxin exerts potent anti-proliferative, anti-migratory, and anti-invasive effects on lung cancer cells [ 23 ]. is sound wave transverse wave

Convallatoxin, the active cardiac glycoside of lily of the valley ...

Convallatoxin inhibits IL-1β production by suppressing …

WebConclusion and implications: We show for the first time that convallatoxin-mediated inhibition of ZFP91 is an important regulatory event that prevents inappropriate … WebIn this study our aim was to evaluate anticancer effects of two naturally occurring CGs, Convallatoxin (CT) and Peruvoside (PS), on ER+ and TNBCs cells. CT and PS demonstrated dose- and time-dependent cytotoxic effect on MCF-7 cells, which was further supported by loss of colony formation on drug treatment. if i hand my notice in can i change my mindWebM2 macrophage polarization has been reported to promote tissue repair and attenuate plaque formation upon the expression of anti-inflammatory factors. Convallatoxin (CNT) is a natural cardiac glycoside with anti-inflammatory pharmacological properties. However, whether CNT protects against atherosclerosis (AS) and underlying mechanisms is … if i had your face genre

"WebApr 16, 2024 · The latter contains up to 40 different cardenolide glycosides of which convallatoxin is the major toxin causing cardiac arrhythmia. Convallaria majalis L. ... All parts of the plant contain the toxic cardenolide glycosides which are only formed in the above surface organs of the plant. Highest toxin concentrations are found in very young … " - Drugs containing convallatoxin

Drugs containing convallatoxin

Convallatoxin inhibits IL‐1β production by suppressing zinc finger ...

WebMar 24, 2014 · Autophagy and apoptosis are important processes that control cellular homeostasis and have been highlighted as promising targets for novel cancer therapies. Here, we identified convallatoxin (CNT), isolated from Antiaris toxicaria, as a dual inducer of autophagy and apoptosis. CNT exerts cytotoxic effects on a number of cancer and … WebNov 26, 2024 · Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Yue …

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WebFeb 20, 2024 · Opioids have long been used to treat severe pain 1.However, long-term use leads to tolerance, dependence and addiction 2.No currently available drugs can completely substitute for opioids in … WebObjectives: To explore the luminescent oxygen channeling technology-based digoxin immunoassay (LOCI digoxin assay) for rapid detection of lily of the valley extract and convallatoxin. The potential in vitro binding of convallatoxin with Digibind was also evaluated. Methods: Aliquots of a drug-free serum pool and a digoxin serum pool were …

WebNov 14, 2024 · Convallatoxin inhibits the proliferation of K562 cells, promotes mitochondria-related apoptosis, and induces cell cycle arrest in the S and G2/M phases, which are related to the downregulation of Akt …

WebNov 26, 2024 · Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Yue Xing, Yue Xing. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian … WebNov 10, 2014 · Convallatoxin is major cardenolide present in A. toxicaria (Agrawal et al., 2014). ... Ecological studies in Antiaris toxicaria, salacia chinensis and Saraca asoca from konkan region of ...

WebSep 30, 2024 · Convallatoxin (CNT) is a natural cardiac glycoside with anti-inflammatory pharmacological properties. ... (Zhong Qiao Xin Zhou Biotechnology, China) were cultured in DMEM medium (12100–046, Gibco, USA) containing 10% FBS (SH30084.03, Hyclone, USA). The cells were plated, and exposed to ox-LDL (100 μg/mL; UnionBiol, China) …

WebConvallatoxin is used as a cardiotonic. The dried rhizome, known as Convallaria root, has also been used as a cardiotonic and diuretic. In veterinary science, it has been used as a diuretic and cardiac stimulant. Cardiac glycosides compounds are potent inhibitors of cellular Na + /K + -ATPase. is sounguesu legitWebApr 12, 2004 · There are over 30 glycosides and convallatoxin is the most toxic with an LD50 of 0.08 mg/kg body weight ( Fenton, 2002 ). Convallatoxin produces cardiac … is soundwise hearing aids legitWebconvallatoxin: ( kon'val-ă-toks'in ), A toxic glycoside isolated from lily of the valley ( Convallaria majalis ); used as a radiotonic agent and for its digitalislike actions. if i hand in my notice can i claim benefitsWebagainst cardiac dysfunction.Standardized convallaria drug powder contains 0.2 to 0.3% cardiac glycosides and is adjusted to a pharmacological activity equivalent to 0.2% … if i hate my job should i quitWebConvallatoxin was obtained from Pfaltz & bauer (Waterbury, CT, USA). Peruvoside was purchased from Research Plus, Inc. (Barnegat, NJ, USA). Strophanthidin, Thiazolyl blue … is sound waves a electromagnetic waveWebSep 1, 2012 · Lily of the Valley Root (Convallaria) 100-400 mg per day, containing Convallatoxin (Convallaria alkaloid) 0.4 mg bid … is soup a healthy breakfastWebThe plant Digitalis purpurea (foxglove) contains the cardioactive glycoside digoxin. In the lily family, squill ( Scilla maritima) contains scillaren, and lily of the valley ( Convallaria … is soup and stew the same thing